Preparing with the ToolChain

I've spent most of the day today trying to figure out how to create the art work required for the game ill' be making.. i've decided that ill' be making a 2D game with 3D renders.. so I have been looking at blender's options tinkering around with it.. to get the right data. I've still got this question about using opengl or pygame ... but most probably ill' stick with just pygame library. But this might change.. just in case.. i learn the glsl shaders usage in pyglet or pyopengl.